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Association details:
Biomarker:ASXL1 overexpression
Cancer:Adrenal Cortex Carcinoma
Regimen:EDP (cisplatin + doxorubicin hydrochloride + etoposide IV)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Source:
Title:

ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen

Published date:
09/18/2021
Excerpt:
ASXL1 overexpression was associated with recurrence and worsened prognosis in ACC. ASXL1 gain was associated with resistance to etoposide, doxorubicin and cisplatin (EDP).