The median age is 75 years (range, 46-92); 73 in the FL cohort and 75.5 in the R/R cohort...Mutations of note in the frontline cohort were TET2 (35%), ASXL1 (30%), RUNX1 (24%), TP53 (16%), and DNMT3A (11%)...In the R/R cohort, the overall response rate is 53% (6 CR, 1 CRi, 1 MLFS with 7 non-responders). Both cohorts received a median of 3 cycles (range for both cohorts, 1-8). With a median follow-up of 7 months, the median survival for the FL cohort is 9.5 months (range, 0.6 – 11.1)...ASTX727 and venetoclax combination is safe and feasible particularly in the advanced elderly population and demonstrates significant efficacy in pts unfit for chemotherapy both in the FL and R/R settings. Total oral therapy of ASTX727 and venetoclax combination appears to be a promising strategy for older and unfit patients with AML.