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Association details:
| Biomarker: | ARG2 underexpression |
|---|---|
| Cancer: | Small Cell Lung Cancer |
| Drug: | pegylated recombinant human arginase (BCT-100) (Arginase replacement) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Endogenous arginase 2 as a biomarker for PEGylated arginase 1 treatment in squamous cell lung carcinoma xenograft models.
Published date:
05/16/2018
Excerpt:
The in vivo effect of PEGylated arginase 1 was studied using 3 lung SCC xenograft models (SK-MES-1, SW900 and H520)....PEGylated arginase 1 treatment was effective in lung SCC xenograft with low endogenous ARG2 expression.
DOI:
10.1200/JCO.2018.36.15_suppl.e20538
