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    Association details:
    Biomarker:AR-V7 expression
    Cancer:Prostate Cancer
    Drug:Opdivo (nivolumab) (PD1 inhibitor) +
    Yervoy (ipilimumab) (CTLA4 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    Prostate
    Title:

    Nivolumab plus ipilimumab, with or without enzalutamide, in AR-V7-expressing metastatic castration-resistant prostate cancer: A phase-2 nonrandomized clinical trial

    Published date:
    02/26/2021
    Excerpt:
    Nivolumab plus ipilimumab demonstrated only modest activity in patients with AR-V7-expressing prostate cancer...
    DOI:
    10.1002/pros.24110