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    Association details:
    Biomarker:AR-V7 expression
    Cancer:Prostate Cancer
    Drug:EPZ004777 (DOT1L inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Nat Commun
    Title:

    Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

    Published date:
    08/19/2020
    Excerpt:
    ...we treated a panel of PCa cell lines with specific DOT1L inhibitor EPZ004777, AR-positive CRPC cells (C42B), AR variant AR-V7 expressing cells (22Rv1) and ENZA resistant cells were all sensitive to DOT1L inhibitor. A second DOT1L inhibitor, EPZ5676, showed similar results as EPZ004777.
    DOI:
    10.1038/s41467-020-18013-7