^
Association details:
| Biomarker: | AR-V7 expression |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | pinometostat (EPZ-5676) (DOT1L inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
Published date:
08/19/2020
Excerpt:
...we treated a panel of PCa cell lines with specific DOT1L inhibitor EPZ004777, AR-positive CRPC cells (C42B), AR variant AR-V7 expressing cells (22Rv1) and ENZA resistant cells were all sensitive to DOT1L inhibitor.
DOI:
10.1038/s41467-020-18013-7
