^
Association details:
| Biomarker: | AR T877A |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | BMS-641988 (Androgen receptor antagonist) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Abstract 5339: Paradoxical androgen receptor regulation by small molecule enantiomers
Published date:
05/15/2020
Excerpt:
...ARE-luciferase, and RT qPCR arrays—confirm that the (R)-enantiomers are potent antagonists of AR in multiple cell lines, including AR T877A mutation-expressing LNCaP and AR overexpressing VCaP. While these cells are virtually resistant to BMS-641988…
DOI:
10.1158/1538-7445.AM2020-5339
