^
Association details:
Biomarker:AR T877A
Cancer:Prostate Cancer
Drug:BMS-641988 (Androgen receptor antagonist)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Title:

Abstract 5339: Paradoxical androgen receptor regulation by small molecule enantiomers

Published date:
05/15/2020
Excerpt:
...ARE-luciferase, and RT qPCR arrays—confirm that the (R)-enantiomers are potent antagonists of AR in multiple cell lines, including AR T877A mutation-expressing LNCaP and AR overexpressing VCaP. While these cells are virtually resistant to BMS-641988…
DOI:
10.1158/1538-7445.AM2020-5339