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Association details:
| Biomarker: | AR positive |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | VNLG-152R (MNK1 degrader, MNK2 degrader) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2
Published date:
09/11/2023
Excerpt:
...oral administration of VNLG-152R and its deuterated analogs in NRG mice. Importantly, in direct comparison, our compounds are more effective than enzalutamide and docetaxel in achieving tumor growth inhibition/repression in the AR+ MDA-MD-453 xenograft model in mice.
DOI:
10.3389/fonc.2023.1240996
