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    Association details:
    Biomarker:AR positive
    Cancer:Triple Negative Breast Cancer
    Drug:deutenzalutamide (HC-1119) (Androgen receptor antagonist)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Mol Biol Rep
    Title:

    HC-1119, a Deuterated Enzalutamide, Inhibits Migration, Invasion and Metastasis of the AR positive Triple-negative Breast Cancer Cells

    Published date:
    03/24/2022
    Excerpt:
    Importantly, cotreatment with HC-1119 of these cells efficiently abolished all of these effects of DHT on both Hs578T and SUM159PT cells. These results indicate that HC-1119 is a very effective new second-generation AR antagonist that can inhibit the migration, invasion and metastasis of the AR-positive TNBC cells.
    DOI:
    https://doi.org/10.21203/rs.3.rs-1415692/v1