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Association details:
| Biomarker: | AR positive |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | enzalutamide deuterated (HC-1119) (Androgen receptor antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
HC-1119, a Deuterated Enzalutamide, Inhibits Migration, Invasion and Metastasis of the AR positive Triple-negative Breast Cancer Cells
Published date:
03/24/2022
Excerpt:
Importantly, cotreatment with HC-1119 of these cells efficiently abolished all of these effects of DHT on both Hs578T and SUM159PT cells. These results indicate that HC-1119 is a very effective new second-generation AR antagonist that can inhibit the migration, invasion and metastasis of the AR-positive TNBC cells.
DOI:
https://doi.org/10.21203/rs.3.rs-1415692/v1
