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    Association details:
    Biomarker:AR positive
    Cancer:Prostate Cancer
    Drug:XY123 (RORγ inverse agonist)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    New
    Source:
    J Med Chem
    Title:

    Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available ROR? Inverse Agonist

    Published date:
    06/14/2021
    Excerpt:
    27h also potently suppressed cell proliferation, colony formation, and the expression of androgen receptor (AR)-regulated genes in AR-positive prostate cancer cell lines.
    DOI:
    10.1021/acs.jmedchem.1c00763