^
Association details:
| Biomarker: | AR expression |
|---|---|
| Cancer: | Prostate Cancer |
| Drug: | SY‑079 (CDK7 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Androgen Receptor Interaction with Mediator Complex is Enhanced in Castration-Resistant Prostate Cancer by CDK7 Phosphorylation of MED1
Published date:
05/01/2020
Excerpt:
...AR-positive PCa cells (LNCaP, VCaP, LAPC4) had increased phosho-MED1 and were more sensitive to THZ1-induced apoptosis than AR-negative PCa cells (DU145, PC3), despite no differences in total CDK7 protein levels…
DOI:
10.1158/2159-8290.CD-19-1028
