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Association details:
| Biomarker: | APC V2194fs + EGFR amplification + EGFR-SEPTIN14 fusion |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | Opdivo (nivolumab) (PD1 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Detection of EGFR-SEPT14 fusion in cell-free DNA of a patient with advanced gastric cancer: A case report
Published date:
04/26/2021
Excerpt:
A 49-year-old female diagnosed with advanced gastric cancer in July 2019 received...nivolumab, but disease progression was observed on a positron emission tomography/computed tomography scan...Therapy was discontinued, and cfDNA next-generation sequencing was immediately evaluated...The following somatic alterations were detected from the patient’s cfDNA: an APC frameshift mutation (NM_000038.5:c.6579del, p.V2194fs)...an EGFR amplification with a copy number of 17.3, and an EGFR-SEPT14 fusion...
DOI:
10.12998/wjcc.v9.i12.2884
