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Association details:
| Biomarker: | APC mutation |
|---|---|
| Cancer: | Colorectal Adenocarcinoma |
| Drug: | ST316 (β-catenin antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
LB045 / 17 - ß-catenin antagonist peptide, ST316, attenuates Wnt-dependent oncogenic activity
Published date:
03/09/2022
Excerpt:
A significant anti-proliferative and dose-dependent cytotoxic effect was observed on HCT116 cells 48 hours post ST316 exposure, with an EC50 of 4.4 µM, and on patient-derived, APC-mutant colorectal adenocarcinoma…
