All CRC cases were at pathological stage III and were treated with standard surgical resection followed by adjuvant chemotherapy with the mFOLFOX6 regimen (5-fluorouracil, leucovorin, and oxaliplatin)….Kaplan–Meier analysis of patients (Fig. 6 a and c) with sequential KRAS, APC or BRCA2, APC somatic mutations also revealed a significantly poor survival outcome...The 4-year recurrence-free survival probabilities for patients with KRAS, APC and BRCA2, APC somatic mutations were 40 and 20%, respectively, which were significantly lower than those for patients with APC, KRAS and APC, BRCA2 somatic mutations (72 and 50%, respectively) (Fig. 6).