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    Association details:
    Biomarker:ANIB1 overexpression
    Cancer:Pancreatic Ductal Adenocarcinoma
    Drug:GANT1 (Hedgehog cell-signalling pathway inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Theranostics
    Title:

    Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation

    Published date:
    01/01/2021
    Excerpt:
    PDAC cell lines with AIB1 high expression were more sensitive to SMO inhibitors such as cyclopamine, sonidegib and GANT1 (Figure ​(Figure6C-D6C-D and Figure S13A…SMO inhibitors have potential therapeutic effects on AIB1-high PDAC tumors.
    DOI:
    10.7150/thno.47390