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Association details:
| Biomarker: | ALPP expression |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | SGN-ALPV (Microtubule inhibitor, ALPP-targeted antibody-drug conjugate, ALPPL2-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1766 / 18 - SGN-ALPV a novel, investigational vedotin ADC demonstrates highly effective targeting of oncofetal phosphatases ALPP and ALPPL2 in preclinical models
Published date:
03/09/2022
Excerpt:
...SGN-ALPV exhibits robust antitumor activity in cell line- and patient-derived xenograft models of ovarian, lung, pancreatic, and gastric carcinoma including models with both homogenous and heterogeneous expression of ALPP and ALPPL2, consistent with robust bystander activity of vedotin ADCs.
