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Association details:
| Biomarker: | ALK rearrangement + EGFR D761N + KRAS V14I |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Xalkori (crizotinib) (ALK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Acquired Resistance Mutations to ALK Inhibitors Identified by Single Circulating Tumor Cell Sequencing in ALK-Rearranged Non-Small-Cell Lung Cancer
Published date:
08/22/2019
Excerpt:
We asked whether single circulating tumor cell (CTC) sequencing can inform on resistance mutations to ALK inhibitors and underlying tumor heterogeneity in ALK-rearranged NSCLC....We investigated the VAF of resistance mutations in CTCs from 14 ALK-rearranged patients progressing on crizotinib...P16 presented EGFRD761N and KRASV14I mutations in different CTC specimens (VAF, 31% and 49% respectively) and additional 14 “off-target” mutations (VAF range, 3%–32%), all in distinct CTC specimens.
DOI:
10.1158/1078-0432.CCR-19-1176
