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Association details:
Biomarker:ALK positive + EML4-ALK fusion + TP53 mutation
Cancer:Lung Adenocarcinoma
Regimen: (Avastin (bevacizumab) + carboplatin + paclitaxel + Tecentriq (atezolizumab))
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C4 – Case Studies
Title:

Remarkable Clinical Response of ALK-Rearranged/TP53-Mutant Lung Adenocarcinoma with Liver Metastasis to Atezolizumab-Bevacizumab-Carboplatin-Paclitaxel After ALK Inhibitors: A Case Report

Published date:
06/23/2023
Excerpt:
We report the case of a 42-year-old male patient with ALK-positive lung adenocarcinoma...Biopsy of the liver metastases revealed echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) fusion and tumor protein p53 (TP53) mutation...the patient exhibited a remarkable clinical response to treatment with a combination of atezolizumab, bevacizumab, carboplatin, and paclitaxel (ABCP).
DOI:
https://doi.org/10.2147/OTT.S404035