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Association details:
Evidence:
Evidence Level:
Resistant: C4 – Case Studies
New
Title:

Identification of I1171N resistance mutation in ALK-positive non-small-cell lung cancer tumor sample and circulating tumor DNA

Excerpt:
We report the case of a patient with ALK-rearranged NSCLC who presented acquired resistance to crizotinib and then alectinib. Sequencing analyses of DNA from a liver metastasis biopsy sample and circulating tumor DNA both found the same I1171N ALK kinase domain mutation, known to confer resistance to certain ALK inhibitors.
DOI:
10.1016/j.lungcan.2016.06.010