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Association details:
| Biomarker: | ALK fusion + ALK G1202R |
|---|---|
| Cancer: | Small Cell Lung Cancer |
| Drug: | Alecensa (alectinib) (ALK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
EP14.01-007 Next-Generation Sequencing to Dynamically Detect Mechanisms of Resistance to ALK Inhibitors in ALK-positive SCLC Patient: A Case Report
Published date:
07/12/2022
Excerpt:
We present the case of a 26-year-old man who was diagnosed with ALK-positive extensive-stage SCLC...After 2 cycles of Alectinib, the CT scan showed a partial response. However, after 9 cycles of treatment, a metastatic lesion enlarged and a new brain lesion appeared....NGS analysis of a series of liquid biopsies revealed a new mutation, ALK p.G1202R, which resulted in resistance to Alectinib... The patient is currently receiving Anlotinib in combination with CPT-11 and is stable with an OS of more than 18 months.
