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Association details:
Biomarker:
ALK F856S
Cancer:
Leukemia
Drug:
TAE-684
(
ALK inhibitor
,
LRRK2 inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Cancer Res
Title:
Therapeutically targetable ALK mutations in leukemia
Excerpt:
NVP-TAE684 inhibited the cell survival and proliferation of Ba/F3 ALK A348D and ALK F856S cells with IC50s of 2.5 nM and ~0.5 nM respectively.
DOI:
https://dx.doi.org/10.1158%2F0008-5472.CAN-14-1576
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