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Association details:
Biomarker:
ALK F856S
Cancer:
Leukemia
Drug:
GSK 1838705A
(
IGF-1R inhibitor
,
Insulin receptor antagonist
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Cancer Res
Title:
Therapeutically targetable ALK mutations in leukemia
Excerpt:
GSK1838705A...was also highly potent in inhibiting growth of ALK-transformed cell lines with IC50s of 18 nM and 2nM for the A348D and F856S cells respectively.
DOI:
10.1158%2F0008-5472.CAN-14-1576
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