^
Association details:
Biomarker:ALK F856S
Cancer:Leukemia
Drug:Zykadia (ceritinib) (ALK inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Title:

Therapeutically targetable ALK mutations in leukemia

Excerpt:
LDK378...inhibited ALK A348D cell growth with an IC50 of 22 nm and F856S cell growth with an IC50 of 4 nM.
DOI:
https://dx.doi.org/10.1158%2F0008-5472.CAN-14-1576