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Association details:
Biomarker:
ALK F1174C
Cancer:
Non Small Cell Lung Cancer
Drug:
Zykadia (ceritinib)
(
ALK inhibitor
)
Direction:
Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
New
Source:
Cancer Sci
Title:
Drug resistance in anaplastic lymphoma kinase-rearranged lung cancer
Excerpt:
G1202R, F1174C/L/V, and G1123S mutations have been found to be ceritinib‐resistant in an analysis of patients treated with ceritinib after crizotinib
DOI:
10.1111/cas.13504
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