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Association details:
| Biomarker: | ALK A348D |
|---|---|
| Cancer: | Leukemia |
| Drug: | TAE-684 (ALK inhibitor, LRRK2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Therapeutically targetable ALK mutations in leukemia
Excerpt:
NVP-TAE684 inhibited the cell survival and proliferation of Ba/F3 ALK A348D and ALK F856S cells with IC50s of 2.5 nM and ~0.5 nM respectively.
DOI:
https://dx.doi.org/10.1158%2F0008-5472.CAN-14-1576
