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Association details:
| Biomarker: | ALDH2 underexpression |
|---|---|
| Cancer: | Squamous Cell Carcinoma of Head and Neck |
| Drug: | 5-fluorouracil (Thymidylate synthase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Analysis of Aldehyde Dehydrogenase 2 as a Prognostic Marker Associated with Immune Cell infiltration and Chemotherapy Efficacy in Head and Neck Squamous Cell Carcinoma
Published date:
06/12/2023
Excerpt:
We next used the data from several in silico studies to examine whether the ALDH2 levels conferred drug resistance....In vitro, low ALDH2 levels showed reduced response to 5-fluorouracil in HNSC-derived cell lines….These findings suggest that ALDH2 could be a potential biomarker in improving risk stratification and tailoring treatment strategies in HNSC patients…
DOI:
10.7150/jca.85098
