^
Association details:
| Biomarker: | ALDH1A1 overexpression |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | erlotinib (EGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Aldehyde dehydrogenase 1A1 confers erlotinib resistance via facilitating the reactive oxygen species-reactive carbonyl species metabolic pathway in lung adenocarcinomas
Published date:
09/23/2019
Excerpt:
Comprehensive assays were performed in a panel of lung adenocarcinoma cell lines and xenografts that acquired resistance to erlotinib….ALDH1A1 overexpression was sufficient to induce erlotinib resistance.
DOI:
10.7150/thno.35729
