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Association details:
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
New
Title:

Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

Excerpt:
We analyzed 100 tumor samples from 44 patients (median progression free survival or PFS = 145 days; range = 84 to 489) (Table 1; Fig. 1A; Supplementary Fig. S1 and Table S1) whose melanomas developed acquired resistance to either vemurafenib or dabrafenib monotherapy....Accordingly, when treated with vemurafenib, WM2664 over-expressing PIK3R2 N561D was more resistant to BRAF inhibition compared with WM2664 introduced with the vector or wild type PIK3R2 (Fig. 3C).
DOI:
10.1158/2159-8290.CD-13-0642