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Association details:
| Biomarker: | AKT1 overexpression |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
AKT isoforms have discrete expression in triple negative breast cancers and roles in cisplatin sensitivity
Published date:
11/10/2020
Excerpt:
AKT1 overexpressed cells were found to be most sensitive to cisplatin treatment at all concentrations of cisplatin tested (0, 0.5, 1, 10, and 50 μM) in both MCF-10A and BT-549…In conclusion, our study demonstrated the varied expression of AKT isoforms in triple-negative breast cancers and also confirmed differential role of isoforms in stemness, invasiveness and response towards the cisplatin treatment.
DOI:
10.18632/oncotarget.27746
