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    Association details:
    Biomarker:AKT1 overexpression
    Cancer:Hormone Receptor Positive Breast Cancer
    Drug:tamoxifen (Estrogen receptor antagonist)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    AACR-NCI-EORTC 2020
    Title:

    Chitinase-like proteins as candidate markers for tamoxifen responsiveness

    Published date:
    10/09/2020
    Excerpt:
    A high expression level of both CHID1 and Akt1 genes was associated with low survival rates in breast cancer patients (log-rank p = 0.031 and log-rank p = 0.044; respectively)....Our preliminary findings suggest that chitinase-like proteins may be involved in the tamoxifen resistance/sensitivity via Akt1-dependent signaling.