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Association details:
| Biomarker: | AKR1C3 overexpression |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug: | OBI-3424 (Alkylating agent) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A novel AKR1C3 specific prodrug TH3424 with potent anti-tumor activity in liver cancer
Excerpt:
TH3424 showed specific killing of liver cancer cells with AKR1C3 overexpression both in vitro and in vivo…TH3424 is a promising drug candidate for liver cancer and other types of cancers overexpressing AKR1C3.
DOI:
10.1002/cpt.2171
