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    Association details:
    Biomarker:AIM2 deletion
    Cancer:Glioblastoma
    Drug:temozolomide (DNA synthesis inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    J Neurooncol
    Title:

    Absent in melanoma 2 regulates tumor cell proliferation in glioblastoma multiforme

    Excerpt:
    This study examined the expression of inflammasome-associated genes in GBM, particularly absent in melanoma 2 (AIM2)….Deletion of AIM2 resulted in significantly enhanced proliferation of U251 cells, which also displayed increased resistance to temozolomide treatment.
    DOI:
    10.1007/s11060-019-03230-y