The two genes predictive for response were analyzed for association with PFS and OS…The two genes predictive for response were analyzed for association with PFS and OS. By univariate analysis, low gene expression of angiotensinogen was significantly associated with prolonged PFS (P = 0.01) and OS (P < 0.01), and high expression of HLA class II (DQA1) was significantly associated with prolonged OS (P = 0.03) but was not associated with PFS (P = 0.16). By multivariate analysis stratified for the prognostic index...low expression of angiotensinogen was independently associated with prolonged PFS (2‐fold decrease: HR = 0.75; 95% CI: 0.59–0.94; P = 0.01) and OS (2‐fold decrease: HR = 0.70; 95% CI: 0.54–0.94; P = 0.005), while HLA class II (DQA1) expression did not significantly influence PFS or OS.