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Association details:
| Biomarker: | AGR2 overexpression |
|---|---|
| Cancer: | Head and Neck Cancer |
| Drug: | docetaxel (Tubulin polymerization promoter, Microtubule stabilizer) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Biomarker discovery for practice of precision medicine in hypopharyngeal cancer: a theranostic study on response prediction of the key therapeutic agents
Published date:
07/16/2022
Excerpt:
...we identified the most correlative genes (and/or proteins) with cellular sensitivity to docetaxel (TXT), cisplatin (CDDP) and 5-fluorouracil (5-FU) in the expression levels...Among these, AGR2, PDE4D and RAB15 were positively correlated with the IC50 values of TXT, indicating that an increased levels of their expression caused an increase of cellular resistance to the drug....
DOI:
10.1001/jamaoncol.2022.0503
