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Association details:
Evidence:
Evidence Level:
Resistant: D – Preclinical
Source:
Title:

Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses

Published date:
01/02/2020
Excerpt:
Notably, all tested cell lines carrying BRAF fusions were resistant to vemurafenib and dabrafenib, sharply distinguishing them from BRAFV600E mutant cell lines…although they harbored the exact same AGK-BRAF fusion. Globally, the C022 cell line showed a higher level of resistance to the tested drugs than C0902 (Figure 4a).
DOI:
10.1016/j.celrep.2019.09.009
Evidence Level:
Resistant: D – Preclinical
New
Title:

Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy

Excerpt:
The AGK-BRAF expressing C0902 cell line showed increased sensitivity to the type II RAF inhibitor sorafenib (IC50 = 410 nM) compared to the BRAFV600E mutant melanoma cell lines A375 (IC50 = 3.0 µM) and SK-MEL-28 (IC50 = 3.1 µM). In contrast, the C0902 cell line showed relative resistance to the type I inhibitor vemurafenib (IC50 = 5.0 µM) compared to the BRAFV600E mutant cell lines (IC50 = 80–92 nM) (Figure 3c).
DOI:
10.1111/pcmr.12148