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Association details:
| Biomarker: | AFAP1-AS1 overexpression |
|---|---|
| Cancer: | Esophageal Squamous Cell Carcinoma |
| Regimen: | FP (5-fluorouracil + cisplatin) |
| Direction: | Resistant |
Evidence:
Source:
Title:
High expression of long non-coding RNA AFAP1-AS1 predicts chemoradioresistance and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy
Excerpt:
All the 204 patients treated with the same dCRT which included 5‐fluorouracial and cisplatin (FP) based regimens….Kaplan–Meier survival analysis revealed that high expression of AFAP1‐AS1 was significantly associated with shorter progression free survival (PFS) (median, 15 months vs. 27 months, P < 0.001) and overall survival (OS) (median, 29 months vs. 42 months, P < 0.001)...high expression of AFAP1‐AS1 could serve as a potential biomarker to predict tumor response and survival. Determination of this lncRNA expression might be useful for selection ESCC patients for dCRT.
DOI:
10.1002/mc.22454
