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Association details:
| Biomarker: | ACVR1 R206H |
|---|---|
| Cancer: | Glioma |
| Drug Class: | Activin receptor inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma
Excerpt:
...Treatment of immunodeprived mice bearing orthotopic xenografts of H3.3K27M, ACVR1R206H mutant HSJD-DIPG-007 cells with 25 mg/kg LDN-193189 or LDN-214117 for 28 days extended survival compared with vehicle controls…
