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Association details:
Evidence:
Evidence Level:
Sensitive: A2 - Guideline
New
Source:
Title:

Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Excerpt:
The third-generation TKI ponatinib is currently the only option in patients progressing with the T315I mutation.
DOI:
10.1093/annonc/mdw025
Evidence Level:
Sensitive: C1 - Off-label
  (Approved for Chronic Myeloid Leukemia)
New
Excerpt:
Iclusig is indicated in adult patients with:...chronic-phase, accelerated-phase or blast-phase chronic myeloid leukaemia (CML) who are resistant to dasatinib or nilotinib, who are intolerant to dasatinib or nilotinib and for whom subsequent treatment with imatinib is not clinically appropriate, or who have the T315I mutation...
Evidence Level:
Sensitive: C2 – Inclusion Criteria
New
Title:

A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Excerpt:
...Participants must have a diagnosis of Ph+ ALL, Philadelphia chromosome-positive plus mixed phenotype acute leukemia (Ph+ MPAL), or Ph-like ALL with: a) Involvement of BM with ALL, including one of the following: i. M2 BM (5%-24% lymphoblasts): by morphology with confirmatory testing consisting of at least one of the following: flow cytometry lymphoblasts ≥5%, or BCR-ABL1 fluorescence in situ hybridization, or ≥10-2 leukemic clone identified by immunoglobulin heavy chain-T-cell receptor polymerase chain reaction, OR ii. ...
Trial ID: