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Association details:
| Biomarker: | ABCC1 expression |
|---|---|
| Cancer: | Sarcoma |
| Drug: | docetaxel (Tubulin polymerization promoter, Microtubule stabilizer) + ifosfamide (Bifunctional alkylating agent) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Analysis of Multiple Drug Resistance Mechanism in Different Types of Soft Tissue Sarcomas: Assessment of the Expression of ABC-Transporters, MVP, YB-1, and Analysis of Their Correlation with Chemosensitivity of Cancer Cells
Published date:
03/16/2022
Excerpt:
...soft tissue sarcomas (STS)…Chemosensitivity (SI) of STS to doxorubicin (Dox), ifosfamide (Ifo), gemcitabine (Gem), and docetaxel (Doc) was analyzed in vitro. In synovial sarcomas we demonstrated positive correlation of ABCC1 expression with SI (Ifo) and SI (Dox + Ifo) as well as ABCG2 expression gene with SI (Doс).
DOI:
10.3390/ijms23063183
