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    Association details:
    Biomarker:ABCB6 expression
    Cancer:Non Small Cell Lung Cancer
    Drug:gemcitabine (DNA synthesis inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    Cell Mol Life Sci
    Title:

    HIF-1-dependent heme synthesis promotes gemcitabine resistance in human non-small cell lung cancers via enhanced ABCB6 expression

    Published date:
    06/04/2022
    Excerpt:
    ...an analysis of ABCB6 expression in human NSCLCs was found to be associated with poor prognosis and gemcitabine resistance in a hypoxia-inducible factor (HIF)-1-dependent manner.
    DOI:
    10.1007/s00018-022-04360-9