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Association details:
| Biomarker: | 35-gene signature |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug Class: | CDK4 inhibitor + CDK6 inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
Activation of the interferon signaling pathway is associated with resistance to CDK4/6 inhibitors and immune checkpoint activation in ER-positive breast cancer
Published date:
02/03/2021
Excerpt:
Transcriptomic analysis of these cell lines identified an association between high interferon (IFN) signaling and reduced CDK4/6i sensitivity; thus an 'IFN-Related Palbociclib-Resistance Signature' (IRPS) was derived. In two neoadjuvant trials of CDK4/6i plus endocrine therapy, IRPS and other IFN-related signatures were highly enriched in patients with tumors exhibiting intrinsic resistance to CDK4/6i.
DOI:
10.1158/1078-0432.CCR-19-4191
