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BIOMARKER:
EML4-ALK rearrangement
i
Other names:
EML4, EMAP Like 4, Restrictedly Overexpressed Proliferation-Associated Protein, Echinoderm Microtubule-Associated Protein-Like 4, Echinoderm Microtubule Associated Protein Like 4, Ropp 120, C2orf2, EMAP-4, EMAPL4, ROPP120, ELP120, NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
;
27436
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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Associations
(5)
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almost3years
von Buttlar et al. described a pt w/ EGFR-mutant advanced #NSCLC who developed acquired EML4-ALK rearrangement mediated resistance to osimertinib, which was overcome by osimertinib + alectinib. https://t.co/e2K9I2DjCp @chulkimMD @StephenVLiu @Joshua_Reuss @JTOonline #JTOCRR #LCSM (@IASLC)
almost 3 years ago
EGFR (Epidermal growth factor receptor) • ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4)
|
EGFR mutation • ALK rearrangement • EML4-ALK rearrangement
|
Tagrisso (osimertinib) • Alecensa (alectinib)
almost3years
von Buttlar et al. described a pt w/ EGFR-mutant advanced #NSCLC who developed acquired EML4-ALK rearrangement mediated resistance to osimertinib, which was overcome by osimertinib + alectinib. https://t.co/N7ZBMPEjZm @chulkimMD @StephenVLiu @Joshua_Reuss @IASLC #JTOCRR #LCSM (@JTOonline)
almost 3 years ago
EGFR (Epidermal growth factor receptor) • ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4)
|
EGFR mutation • ALK rearrangement • EML4-ALK rearrangement
|
Tagrisso (osimertinib) • Alecensa (alectinib)
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