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BIOMARKER:

EGFR amplification

i
Other names: EGFR, ERBB, ERBB1, Epidermal growth factor receptor
Entrez ID:
10ms
IO biomarker
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR amplification • EGFR R521K
|
albumin-bound paclitaxel • TheraCIM (nimotuzumab)
1year
Clinical
|
EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2)
|
HER-2 amplification • EGFR amplification
over1year
Clinical • Next-generation sequencing
|
EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • CLDN18 (Claudin 18)
|
EGFR mutation • HER-2 negative • EGFR amplification
|
Erbitux (cetuximab) • albumin-bound paclitaxel • Cyramza (ramucirumab) • irinotecan • TheraCIM (nimotuzumab)
over1year
Clinical • HEOR • Real-world evidence
|
EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase)
|
EGFR amplification
over2years
EGFR (Epidermal growth factor receptor)
|
EGFR amplification
|
Tukysa (tucatinib)
over2years
Clinical
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR amplification • EGFRvIII mutation
|
Avastin (bevacizumab) • Tagrisso (osimertinib)
over2years
EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1)
|
HER-2 amplification • HER-2 negative • EGFR amplification
over2years
EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1)
|
HER-2 amplification • EGFR amplification
|
Opdivo (nivolumab) • 5-fluorouracil • leucovorin calcium
3years
Clinical • Next-generation sequencing
|
EGFR (Epidermal growth factor receptor) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B)
|
EGFR amplification • miR-138 underexpression + miR-497 overexpression
|
Tagrisso (osimertinib)