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    BIOMARKER:

    CTNNB1 mutation

    i
    Other names: CTNNB1, armadillo, beta-catenin, CTNNB, Catenin (cadherin-associated protein), beta 1
    Entrez ID:
    1499
    Related biomarkers:
    Expression
    Mutation
    Others
    over1year
    💎#Desmoid 🔹Beta-catenin, CTNNB1 mutation Mx: 🔹Asymptomatic →Active surveillance, C-scope (FAP) 🔹Resection (30% recurrence) 🔹Unresectable/Recurrent/Margin+ →XRT 🔹Systemic Rx: Tamoxifen, NSAIDs, Chemotherapy and TKIs #MedTwitter #OncTwitter #sarcoma #oncology (@dawood_findakly)
    CTNNB1 (Catenin (cadherin-associated protein), beta 1)
    |
    CTNNB1 mutation
    |
    tamoxifen
    over1year
    Endometrial cancers with CTNNB1 mutations appear to respond better to bevacizumab treatment and a potential mechanism is now revealed; https://t.co/ugacGgXruD (@levinemd)
    CTNNB1 (Catenin (cadherin-associated protein), beta 1)
    |
    CTNNB1 mutation
    |
    Avastin (bevacizumab)
    2years
    Prospective French cohort study;results of 516 pts. Lack of prognostic value (EFS) of CTNNB1 mutation profile in Desmoid Fibromatosis (also not of p.S45F despite being associated with worse prognostic factors: male, large tumour, non-abdominal wall, pain) https://t.co/5GH5ZgrOXE (@Winette_vdGraaf)
    Clinical
    |
    CTNNB1 (Catenin (cadherin-associated protein), beta 1)
    |
    CTNNB1 mutation
    over3years
    Long-term outcomes of oral vinorelbine in advanced, progressive desmoid fibromatosis and influence of CTNNB1 mutational status https://t.co/hgrynZVkd1 (@Winette_vdGraaf)
    CTNNB1 (Catenin (cadherin-associated protein), beta 1)
    |
    CTNNB1 mutation
    |
    vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    4years
    Congrats to #DHPath residents Chris Jackson and @MindiolaMD at #USCAP2020 for posters on a machine learning algorithm for virtual SOX10 IHC and CTNNB1 mutations in NSCLC. #lung #MachineLearning (@LJTafeMD)
    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • SOX10 (SRY-Box 10)
    |
    CTNNB1 mutation