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Filter by
Latest
9ms
Nice shoutout to Dr @RonaYaeger trial Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer NCT05710406 public post w/ more info https://t.co/hbemZq4P6a #gdugi2023 (@fireflyann)
9 months ago
Surgery
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation
9ms
Things may be looking up in #coloncancer care as data from ongoing trials is uncovered. Explore metastatic #colorectalcfancer further with Dr. Charles Turck as he speaks with @MoffittNews’ Dr. Richard Kim and @benweinbergmd from @MedStarHealth: https://t.co/XtIKiAH16R (@ReachMD)
9 months ago
Metastases
|
FANCE (FA Complementation Group E)
9ms
LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3: https://t.co/JIvStFdT5H @ARustgi @ColumbiaCancer #Gastroenterology #Oncology (@JCI_insight)
9 months ago
NOTCH3 (Notch Receptor 3) • CLDN1 (Claudin 1) • LIN28B (Lin-28 Homolog B)
9ms
ASCI member @ARustgi @ColumbiaCancer in @JCI_insight: LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3: https://t.co/Y3cVAu3zAu #Gastroenterology #Oncology (@the_asci)
9 months ago
NOTCH3 (Notch Receptor 3) • CLDN1 (Claudin 1) • LIN28B (Lin-28 Homolog B)
9ms
We had summarized some of the HER2 data in colorectal cancer. The space in cholangiocarcinoma is quickly expanding with bispecifics and other drugs as mentioned. Choose/pivot to #clinicaltrials. If not available, choose something that has ✅blood brain barrier 🧠 penetration. https://t.co/9HKqjJ8EkS (@pashtoonkasi)
9 months ago
Clinical
|
HER-2 (Human epidermal growth factor receptor 2)
9ms
You can learn more about the S2107 trial for patients with #CRC that has a BRAF gene change at https://t.co/xuyNsoZ7Ol and at https://t.co/6zyVZagFZj. Wishing all the best to your mom, @precisionmbm! #CRCSM (@SWOG)
9 months ago
Clinical
|
BRAF (B-raf proto-oncogene)
9ms
The BRAF V600E mutation in #coloncancer carries distinct implications and affects 5-15% of cases, leading to a poorer prognosis. Learn about the latest #treatment strategies and expert insights from Dr. Rona Yaeger at #ASCO23. @RonaYaeger https://t.co/Jn6B8zYvYS (@oncologytube)
9 months ago
Clinical
|
BRAF (B-raf proto-oncogene)
|
BRAF V600E • BRAF V600
9ms
During the GI Cancer Committee session, Dr. Thom George provides an update on the GI004 COMMIT study, currently enrolling patients with metastatic adenocarcinoma of the colon or rectum. This is the last session of #NRG2023. @TGeorgeMD (@NRGonc)
9 months ago
Clinical • Metastases
|
NRG2 (Neuregulin 2)
9ms
I’m spoiled➡️Rectal Cancer Trial options: ✔️an investigator trial of AB928 Dual Adenosine Receptor Antagonist💊➕AB122 (a PD1⛔️) (PANTHER)➕☢️ ✔️JANUS @JoshSmithMDPhD @ALLIANCE_org 🔌 ✔️ROBIN 💡Add preference for short course☢️in oligo-metastatic to avoid breaks. #CRCSM (@pashtoonkasi)
9 months ago
Metastases
|
PD-1 (Programmed cell death 1)
|
Yutuo (zimberelimab) • etrumadenant (AB928)
9ms
#Tucatinib + #Trastuzumab was approved earlier this year for refractory mCRC HER 2 positive disease. Previously, we had also discussed the implications of anti-egfr therapy w/ @GIcancerDoc and @CathyEngMD in this subset + RAS WT. This study by @GIcancerDoc continues to support:… https://t.co/16FDqtJdMS (@OncBrothers)
9 months ago
HER-2 positive • RAS wild-type
|
Herceptin (trastuzumab) • Tukysa (tucatinib)
9ms
#EOCRC #EAOCRC @Lynchsyndromirl @FightCRC @CGAIGC @insightmeeting @IEColonCancer @CRCequity @TheColonClub @AGA_Gastro @ASCO @ASCOPost @AACR (@FASinicropeMD)
9 months ago
9ms
Great work by the team around @FilippoPietran4, @ChiaraCrem1 and @sara_lonardi1 investigating ICI in dMMR #colorectalcancer 👉TMBhigh: excellent response 👉TMBlow: poor response 👉more biomarkers needed for TMB intermediate 🧐 @OncoAlert 🚨 https://t.co/lBveXH6apZ (@heinrich_kat)
9 months ago
TMB (Tumor Mutational Burden)
|
MSI-H/dMMR • TMB-L
9ms
And yet we have update to NCCN for dMMR colon cancer with ICI, based on less numbers and very short follow up 🤷♂️ Let’s not try to make a L from what is clearly a W. We need a STABLE-MATES type trial of SBRT + IO vs. sublobar/lobar resection. Organ preservation! (@5_utr)
9 months ago
MSI-H/dMMR
9ms
7/Key Study Findings🔑 🌟Patients >75yr had very🔽low rate (0.2%) of invasive colorectal adenocarcinoma 🦀 🌟Invasive CRC🦀 patients with a life expectancy <10 years: only 1 of 9 received 🦀 treatment 🌟Patients >85yr had⬆️adverse 🚫event rate @ 10 days 🟰⬆️Risk ⬇️Benefit (@Montalvan214)
9 months ago
Clinical • Adverse events
9ms
Association of Genetic Ancestry with Molecular Tumor Profiles in Colorectal Cancer {preprint} [Jul 12, 2023] @RheadBrooke et al. @ribozyme @NiuSanford @medrxivpreprint https://t.co/T70g0XLmXF #GeneticCounselors #crcsm #PrecisionMedicine @UTSWNews @TempusLabs (@mtmdphd)
9 months ago
Preprint
9ms
On this JCO Precision Oncology Conversations podcast episode, host @thenasheffect speaks w/ Dr. Alicia Latham about her #JCOPO article, Prevalence & Clinical Implications of Mismatch Repair-Proficient Colorectal Cancer in Patients w/ Lynch Syndrome. https://t.co/pkgaCft9r2 #crcsm (@JCOPO_ASCO)
9 months ago
Clinical • Mismatch repair
9ms
This @TumoirJ research explores #prognostic and #predictive role ➡️TK-1, TP, Ang-2, and Tie-2 mRNA expression🧬 in plasma-derived microvesicles 🩸 ➡️Chemo-refractory metastatic #ColorectalCancer patients 🔗https://t.co/7wboBZsMZ4 @LorenzaRimassa #gicancers #gastriccancer (@TumoriJ)
9 months ago
Clinical • Metastases
9ms
Adding bevacizumab to trifluridine-tipiracil results in longer overall survival in refractory metastatic colorectal cancer https://t.co/UoVQSGo4CJ #fondazionebonadonna #oncology #CancerResearch @BianchiniGP @CarmenCriscit @mauricallari (@FondazioneBona1)
9 months ago
Clinical • Metastases
|
Avastin (bevacizumab) • Lonsurf (trifluridine/tipiracil)
9ms
While updating the presentation (~ 5 years old) for a student's lecture on #colorectalcancer I was amazed how much I had to change. https://t.co/ba5Zfiucjv I did not even start with neoadjuvant options... @JenSeligmann @MyriamChalabi #CRCSM #CancerResearch @OncoAlert 🚨 (@heinrich_kat)
9 months ago
Clinical
9ms
Now enrolling - @ALLIANCE_org A022004 led by .@RonaYaeger @MSKCancerCenter #NCI #NCTN #CRCsm .@FightCRC .@ColonCancerCoal .@ColonCancerFdn (@ALLIANCE_org)
9 months ago
9ms
Check out Dr. Benjamin Weinberg @benweinbergmd @LombardiCancer discussing Biomarker Study of the PARADIGM Trial: What It Means for the Right Side mCRC #mCRC #GICSM #OncTwitter #MedEd #ctDNA https://t.co/V7mJILXMsh (@Sameh_VuMedi)
9 months ago
Circulating tumor DNA
9ms
“It’s never the wrong time to ask” re: Cachexia and when to ask your doctor about weight loss. Thank you, @DrR_DUNNE and @ctycka for your #CRCWebinar with @FightCRC on Cachexia and Colorectal Cancer. (@Melissa03758144)
9 months ago
9ms
🎉 Celebrating #JCO's 40th: Read Dr. @EileenMOReilly's Flashback Foreword to the top-cited #JCO articles, Bevacizumab and FOLFOX4 for Colorectal Cancer (2008) and Bevacizumab v Placebo Plus Oxaliplatin-Based Chemotherapy in MCRC (2007) 👉 https://t.co/vSh3PLqCmv (@JCO_ASCO)
9 months ago
Clinical
|
Avastin (bevacizumab) • oxaliplatin
9ms
#ct Charity Tuesday @Bowel_Cancer_UK @CR_UK @WRAglobal @Tearfund @christian_aid @macmillancancer @CAFTcharity @childrentoday @OrchidCancer @NSPCC @Retrak_Charity @Hopeforjustice @ProstateUK @DementiaUK @alzheimerssoc @ParkinsonsUK @CureParkinsonsT PLEASE RT (@nigs)
9 months ago
9ms
I’m so sorry for your loss. My younger sister also refused to talk about prognosis and by the time we needed to have certain conversations she couldn’t communicate with us any more. It was horrific. I wish her care could have been more holistic from the outset. @bowelcanceruk (@ElizAthertonSop)
9 months ago
9ms
cc fantastic CRC patient advocate groups/leaders: @manjuggm @colontown @coloncancergal @CCAlliance @coloncancermike (@NiuSanford)
9 months ago
Clinical
9ms
As an airline & military pilot with 8 overseas deployments, Rick was used to planning ahead and sticking to a schedule. A #ColonCancer diagnosis posed a new challenge for him and his wife Sally. Read their #PatientStory: https://t.co/GYqBUMZuQX @MGHSurgery @HodinRichard @TedHong9 (@MGHCancerCenter)
9 months ago
Clinical • Surgery
9ms
.@MayoClinic surgeon @EricDozoisMD explains the different approaches experts take when treating #ColonCancer and #RectalCancer. https://t.co/ThuxB9NFu4 (@MayoCancerCare)
9 months ago
9ms
Optimal maintenance strategy following FOLFOX + anti-EGFR in RAS WT mCRC: individual patient data pooled analysis of 4 clinical trials @OncologyAdvance https://t.co/m0C5Z9Vc3S 👉Low evidence, overall FU/LV + anti-EGFR preferred maintenance, stop & go stillan option @myESMO… https://t.co/VaNKlHpNf3 (@ArndtVogel)
9 months ago
Retrospective data
|
RAS (Rat Sarcoma Virus)
|
RAS wild-type
|
5-fluorouracil • leucovorin calcium
9ms
Cmon @UrviShahMD Between your great work with myeloma and Nutrition are you really sure you don’t want to spend thousands of dollars and answer questions about colon cancer in your limited spare time ? (@JoshuaRichterMD)
9 months ago
9ms
I have a question do you know anyone that has turned down the surgery for rectal cancer and has survived. Because I have rectal cancer and I don't want to get the surgery especially since I'm not having any problems after my radiation and fasting also on a keto diet (@TonyHer63445094)
9 months ago
Surgery
9ms
And capping off the morning, my former boss, the incomparable @Joleen__Hubbard with a stellar presentation on updates in colorectal cancer. Her last formal Mayo act before moving on to the Allina Cancer Center in the Twin Cities. She will be greatly missed at Mayo. (@OncoThor)
9 months ago
9ms
Looking for a neat summary on management of locally advanced rectal cancer? I found one for you, thanks to @Joleen__Hubbard (@OncoThor)
9 months ago
Metastases
9ms
Had a wonderful time with colleagues at @OhioStateSurg division of #colorectalsurgery cookout and farewell party for graduating fellow @bradkras Many thanks to @MattKaladyMD and Skyler Kalady for being such wonderful hosts! PS. 🎂 was awesome! (@Colon_Doc)
9 months ago
Surgery
9ms
Answer (D). 85% of Post-colonoscopy colorectal cancer within <4 years of prior colonoscopy is due to a missed lesion #EBGI Tweetorial 🧵“What are the Causes of Post-Colonoscopy CRC” 📃Summary: https://t.co/c2ylIGnc90 🎧https://t.co/mWg4NyBW6N 📖https://t.co/S2YSKMjF5i #GITwitter (@Chatterjee_MD)
9 months ago
9ms
With the positive results from HIPECT4 (cytoreduction + HIPEC with mitomycin C) for locally advanced colorectal cancer, looking forward to this @alarjosan #medicalinnovation #colorectalcancer #HIPEC #CombatCancer (@CombatCancer)
9 months ago
Metastases
|
mitomycin
9ms
An exciting GI session at the 2nd Pittsburgh Oncology Symposium with expert GI Docs @GIcancerDoc @IbrahimSahinMD1 @AnwaarSaeed3 @NiloferAzad @jajani promising agents in upper GI and colorectal cancers. @HopkinsMedicine @UPMCHillmanCC @MayoClinic @MDAndersonNews @JohnRhe57565741 (@teekayowo)
9 months ago
9ms
In their exciting talk, Dr. @GIcancerDoc and Dr Azad overviewing updates on colorectal cancer and cholangiocarcinoma and precision medicine approaches for these two important diseases‼️ @AnwaarSaeed3 @teekayowo @UPMCHillmanCC #PittsburghOncologySymposium ❗️ (@IbrahimSahinMD1)
9 months ago
9ms
Sylvester Cancer Researcher Honored with ASCO Early Career Award @KumarShria @DrSDNimer @DrTracyECrane @DrLiver @SylvesterCancer @umiamimedicine #crcsm #oncology https://t.co/bQKYglkrEH (@OncLive)
9 months ago
9ms
What is the most likely cause of her post-colonoscopy colorectal cancer? 🔦💩 @john_damianosMD @Dvinsard @PriSantiagoMD @LadyKatherineM1 @APNDMD @KatieFalloonMD @LJanssensMD @VibhuC_MD @DrewfordMD @KhushbooSGala @dunleavy_katie @AbelJosephMD @Jessica_Halabi (@Chatterjee_MD)
9 months ago
9ms
@FF Follow Friday @Bowel_Cancer_UK @CR_UK @WRAglobal @Tearfund @christian_aid @macmillancancer @CAFTcharity @childrentoday @OrchidCancer @NSPCC @Retrak_Charity @Hopeforjustice @ProstateUK @DementiaUK @alzheimerssoc @ParkinsonsUK @CureParkinsonsT PLEASE RT (@nigs)
9 months ago
9ms
Fantastic achievement to see our region influence signing of major agreement between government & @BioNTech_Group 10,000 patients to get access to cancer immunotherapies by 2030 Congratulations @robjones1979 @Jaime_Alvo @LivHospitalsRI @LivHospitals @CCCNHS @LivUni @bowelcanceruk (@NIHRCRN_nwcoast)
9 months ago
Clinical
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