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BIOMARKER:
Chr del(11q)
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Associations
(22)
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Trials
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@AaronGoodman33
@tobyeyre82
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@AaronGoodman33
@tobyeyre82
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Latest
1year
t(11;18) = API2-MALT1 = MZL H. pylori- t(2;5) = NPM1-ALK = ALCL ALK+ t(6;7) = DUSP22-FRAH7H = ALCL ALK- iso7q = HSTCL inv(14) = t(14;14) = MTCP1 = T-PLL t(X;14) = TCL1 = T-PLL del(11q) = ATM = CLL (intermediate) del(13q) = RB1 = CLL (good) +12 = CLL (good) (@AaronGoodman33)
1 year ago
NPM1 (Nucleophosmin 1) • RB1 (RB Transcriptional Corepressor 1) • BIRC3 (Baculoviral IAP repeat containing 3) • MALT1 (MALT1 Paracaspase) • DUSP22 (Dual Specificity Phosphatase 22) • USP22 (Ubiquitin Specific Peptidase 22)
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Chr del(11q)
over1year
Long term follow up of #Acalabrutinib phase I/II trial N=134 R/R CLL/SLL Median 66Y 73% unmut IGHV 27% del17p 20% del11q 35% CK mPFS 66.1m ✅ long term efficacy & safety TP53/p53 del pts still an area of clinical need #CLL #ASH22 #lymsm (@tobyeyre82)
over 1 year ago
Clinical • P1/2 data
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TP53 (Tumor protein P53)
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Chr del(11q) • Chr del(17p) + Chr del(11q)
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Calquence (acalabrutinib)
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