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BIOMARKER:
APOBEC mutagenesis
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Associations
(4)
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over1year
APOBEC mutagenesis "turned on" in EGFR-mutant osimertinib-resistant lung adenocarcinomas https://t.co/GeRnVoDwp4 @HelenaYu923 @christine_lovly @charlesrudin (@MLadanyi)
over 1 year ago
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • APOBEC mutagenesis
|
Tagrisso (osimertinib)
almost2years
Sclc transformation has been associated with Apobec mutagenesis subclonally driving loss of both p53 and RB1 - no obvious C>A signature of tobacco exposure / passive smoking (@CharlesSwanton)
almost 2 years ago
RB1 (RB Transcriptional Corepressor 1)
|
TP53 mutation • APOBEC mutagenesis
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