[{"id":"0340b14e-a127-4e74-868c-fbd3285909ff","acronym":"","url":"https://clinicaltrials.gov/study/NCT05761951","created_at":"2023-03-09T15:01:38.080Z","updated_at":"2025-02-25T16:18:37.564Z","phase":"Phase 2","brief_title":"Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer","source_id_and_acronym":"NCT05761951","lead_sponsor":"M.D. Anderson Cancer Center","biomarkers":" CTNNB1 • AXIN1 • RSPO2 • ZNRF3","pipe":" | ","alterations":" CTNNB1 mutation","tags":["CTNNB1 • AXIN1 • RSPO2 • ZNRF3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e CTNNB1 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Keytruda (pembrolizumab) • sirexatamab (DKN-01)"],"overall_status":"Recruiting","enrollment":" Enrollment 60","initiation":"Initiation: 08/29/2023","start_date":" 08/29/2023","primary_txt":" Primary completion: 01/31/2027","primary_completion_date":" 01/31/2027","study_txt":" Completion: 01/31/2029","study_completion_date":" 01/31/2029","last_update_posted":"2024-11-18"},{"id":"d1c8d534-b991-4bdd-aee5-250c8074853d","acronym":"","url":"https://clinicaltrials.gov/study/NCT03833700","created_at":"2023-07-12T22:09:04.322Z","updated_at":"2024-07-02T16:35:16.167Z","phase":"Phase 1","brief_title":"A Study of E7386 in Participants With Advanced Solid Tumor Including Colorectal Cancer (CRC)","source_id_and_acronym":"NCT03833700","lead_sponsor":"Eisai Co., Ltd.","biomarkers":" RNF43 • APC • AXIN1 • ZNRF3","pipe":" | ","alterations":" APC mutation • CTNNB1 mutation • RNF43 mutation","tags":["RNF43 • APC • AXIN1 • ZNRF3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e APC mutation • CTNNB1 mutation • RNF43 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e E7386"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 70","initiation":"Initiation: 03/05/2019","start_date":" 03/05/2019","primary_txt":" Primary completion: 03/31/2025","primary_completion_date":" 03/31/2025","study_txt":" Completion: 03/31/2025","study_completion_date":" 03/31/2025","last_update_posted":"2024-03-06"}]