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DRUG:
WNT974
i
Other names:
NVP-LGK974, LGK-974, LGK 974, WNT974, LGK974, WNT-974, WNT 974
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Associations
(2)
News
Trials
Company:
Novartis
Drug class:
Wnt signalling pathway inhibitor, PORCN inhibitor
Related drugs:
‹
PRI724 (5)
SM04690 (2)
BC2059 (2)
CGX1321 (1)
NCB-0846 (1)
XAV-939 (1)
OMP-18R5 (1)
CWP291 (0)
Circ0003039 (0)
E7386 (0)
KY1022 (0)
OMP-54F28 (0)
OTSA101-DTPA-90Y (0)
ETC-159 (0)
RXC004 (0)
PRI724 (5)
SM04690 (2)
BC2059 (2)
CGX1321 (1)
NCB-0846 (1)
XAV-939 (1)
OMP-18R5 (1)
CWP291 (0)
Circ0003039 (0)
E7386 (0)
KY1022 (0)
OMP-54F28 (0)
OTSA101-DTPA-90Y (0)
ETC-159 (0)
RXC004 (0)
›
Associations
(2)
News
Trials
Phase
Status
Apply
Phase
Status
Apply
A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands (NCT01351103)
Phase 1
Novartis Pharmaceuticals
Novartis Pharmaceuticals
Active, not recruiting
Phase 1
Novartis Pharmaceuticals
Active, not recruiting
Last update posted :
05/30/2024
Initiation :
12/01/2011
Primary completion :
06/14/2021
Completion :
06/18/2024
BRAF • RNF43
|
BRAF mutation • RNF43 mutation
|
spartalizumab (PDR001) • WNT974
Study of WNT974 in Combination With LGX818 and Cetuximab in Patients With BRAF-mutant Metastatic Colorectal Cancer (mCRC) and Wnt Pathway Mutations (NCT02278133)
Phase 1/2
Array BioPharma
Array BioPharma
Completed
Phase 1/2
Array BioPharma
Completed
Last update posted :
10/09/2017
Initiation :
12/01/2014
Primary completion :
05/31/2016
Completion :
06/23/2017
KRAS • RNF43
|
KRAS mutation • BRAF V600 • KRAS wild-type • RAS wild-type • RNF43 mutation
|
Erbitux (cetuximab) • Braftovi (encorafenib) • WNT974
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