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DRUG:
Vigil (gemogenovatucel-T)
i
Other names:
Bi-shRNAfurin, bi-shRNAfurin/GMCSF augmented autologous tumor cell vaccine, IND14205, TGFbeta2 antisense + rhGMCSF vaccine, TAG vaccine, bi-shRNAfurin/GMCSF autologous tumor cell vaccine
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Associations
News
Trials
Company:
Gradalis
Drug class:
GM-CSF agonist, TGF-β1 inhibitor, TGF-β2 inhibitor
Related drugs:
‹
talimogene laherparepvec (9)
ONCOS-102 (1)
CG0070 (1)
BS001 (0)
allogeneic GM-CSF-secreting tumor cells (0)
GVAX leukemia vaccine (0)
GVAX lung cancer vaccine (0)
sargramostim (0)
filgrastim (0)
OrienX010 (0)
pexastimogene devacirepvec (0)
PSA/IL-2/GM-CSF vaccine (0)
allogeneic Myeloma GM-CSF Vaccine (0)
LY2157299 (3)
AIM-001 (0)
HCW9218 (0)
NCE 401 (0)
RG6440 (0)
YL-13027 (0)
SRK-181 (0)
ABBV-151 (0)
NIS793 (0)
GS 6624 (0)
miRNA-520f (0)
OT-101 (0)
talimogene laherparepvec (9)
ONCOS-102 (1)
CG0070 (1)
BS001 (0)
allogeneic GM-CSF-secreting tumor cells (0)
GVAX leukemia vaccine (0)
GVAX lung cancer vaccine (0)
sargramostim (0)
filgrastim (0)
OrienX010 (0)
pexastimogene devacirepvec (0)
PSA/IL-2/GM-CSF vaccine (0)
allogeneic Myeloma GM-CSF Vaccine (0)
LY2157299 (3)
AIM-001 (0)
HCW9218 (0)
NCE 401 (0)
RG6440 (0)
YL-13027 (0)
SRK-181 (0)
ABBV-151 (0)
NIS793 (0)
GS 6624 (0)
miRNA-520f (0)
OT-101 (0)
›
Associations
News
Trials
Phase
Status
Apply
Phase
Status
Apply
A Trial of Atezolizumab and Vigil in Patients With Advanced Gynecological Cancers (NCT03073525)
Phase 2
Gradalis, Inc.
Gradalis, Inc.
Completed
Phase 2
Gradalis, Inc.
Completed
Last update posted :
04/05/2023
Initiation :
05/31/2017
Primary completion :
05/22/2019
Completion :
05/18/2022
PD-L1
|
PD-L1 expression
|
Tecentriq (atezolizumab) • Vigil (gemogenovatucel-T)
Trial of Bi-shRNA-furin and GMCSF Augmented Autologous Tumor Cell Vaccine for Advanced Cancer (NCT01061840)
Phase 1
Gradalis, Inc.
Gradalis, Inc.
Completed
Phase 1
Gradalis, Inc.
Completed
Last update posted :
03/15/2022
Initiation :
12/01/2009
Primary completion :
12/06/2018
Completion :
01/01/2019
CSF2
|
Vigil (gemogenovatucel-T)
Pilot Study of Durvalumab and Vigil in Advanced Women's Cancers (NCT02725489)
Phase 2
Mary Crowley Medical Research Center
Mary Crowley Medical Research Center
Completed
Phase 2
Mary Crowley Medical Research Center
Completed
Last update posted :
01/27/2021
Initiation :
06/03/2016
Primary completion :
12/30/2019
Completion :
12/02/2020
IFNG
|
PD-L1 expression
|
Imfinzi (durvalumab) • Vigil (gemogenovatucel-T)
Pilot Study of Vigil™ + Pembrolizumab for Advanced Melanoma (NCT02574533)
Phase 1
Gradalis, Inc.
Gradalis, Inc.
Completed
Phase 1
Gradalis, Inc.
Completed
Last update posted :
09/27/2017
Initiation :
10/01/2015
Primary completion :
09/01/2017
Completion :
09/01/2017
PD-L1 • BRAF
|
BRAF mutation
|
Keytruda (pembrolizumab) • Vigil (gemogenovatucel-T)
Vigil™ + Nivolumab in Advanced Non-Small Cell Lung Cancer (NCT02639234)
Phase 2
Gradalis, Inc.
Gradalis, Inc.
Withdrawn
Phase 2
Gradalis, Inc.
Withdrawn
Last update posted :
07/31/2017
Initiation :
03/01/2016
Primary completion :
03/01/2017
Completion :
03/01/2017
EGFR • ALK
|
EGFR mutation • ALK mutation
|
Opdivo (nivolumab) • Vigil (gemogenovatucel-T)
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